PLGF anticorps (AA 206-221)

N° du produit ABIN2743614

Cet anticorps anti-PLGF est un anticorps Lapin Polyclonal détectant PLGF dans WB. Adapté pour Humain, Chimpanzé et Singe.

Aperçu rapide pour PLGF anticorps (AA 206-221) (ABIN2743614)

Antigène: PLGF (PGF) (Placenta Growth Factor (PGF))

Reactivité: Humain, Chimpanzé, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PLGF est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PLGF anticorps

Épitope: AA 206-221

Specificité: Human PGF / PLGF

Purification: Immunoaffinity purified

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human PLGF(206-221aa REKMKPERCGDAVPRR). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Monkey (100%), Cat (88%).

Type of Immunogen: Synthetic peptide

Isotype: IgG

Information d'application

Indications d'application: Approved: WB (0.5 - 1 μg/mL)

Usage: Placental growth factor(PGF, also known as PLGF) codes for an angiogenic factor expressed in placental tissue that is similar to vascular permeability factor/vascular endothelial growth factor(VPF/VEGF). It is a glycosylated dimeric secreted protein able to stimulate endothelial cell growth in vitro. PGF is located on chromosome 14 and has been conserved in evolution. It belongs to the family of vascular endothelial growth factors(VEGFs) and binds to the flt-1 VEGF receptor. PLGF-2, which is a PLGF isoform, binds neuropilin-1 and 2 in a heparin-dependent manner. PGF regulates inter- and intra molecular cross talk between the VEGF RTKs Flt1 and Flk1 and stimulates the phosphorylation of specific Flt1 tyrosine residues and the expression of distinct downstream target genes. Moreover, it plays an important role in pathological angiogenic events and with exerting its biological activities through binding to VEGFR1.

Commentaires:

Target Species of Antibody: Human

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Sterile distilled water

Concentration: Lot specific

Buffer: Lyophilized from PBS, 2.5 % BSA, 0.025 % sodium azide/thimerosal.

Agent conservateur: Sodium azide, Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze/thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for 1 month or -20°C for longer. Avoid freeze/thaw cycles.

Détails sur PLGF

Antigène: PLGF (PGF) (Placenta Growth Factor (PGF))

Autre désignation: PGF / PLGF

Sujet: Name/Gene ID: PGF
Family: PDGF

Synonyms: PGF, D12S1900, PGFL, PlGF-2, Placental growth factor, Placental growth factor-like, PLGF, Placenta growth factor, SHGC-10760

ID gène: 5228

Pathways: VEGFR1 Specific Signals